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英國(guó)癌癥研究人員完整名錄494—3

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Costa, Dr Alessandro alessandro.costa**[ta]**ck.ac.uk

Architecture and Dynamics of Macromolecular Machines The Francis Crick Institute 01/03/2012 28/02/2018 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Cosway, Dr Benjamin benjamin.cosway**[ta]**.ac.uk

Harnessing Autophagy For the Clinical Beneft of Oropharyngeal Squamous Cell Carcinomas Newcastle University 01/07/2015 30/06/2016 Clinical Careers Committee - Research Bursary Clinical Careers Committee

Crabb, Dr Simon S.J.Crabb**[ta]**thampton.ac.uk

CRUKE/12/023: (SAKK08/11) Orteronel maintenance therapy in patients with metastatic castration resistant prostate cancer and non-progressive disease after frst-line docetaxel therapy: A multicenter randomized double-blind placebo-controlled phase III trial University of Southampton 01/11/2012 30/04/2016 Clinical Trials Awards & Advisory Committee - Endorsement - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/12/042: A phase I/randomised phase II study in metastatic castration resistant Prostate Cancer of AZD5363 In combination with Docetaxel and prednisolone chemotherapy (ProCAID) (AZ/NCRN) University of Southampton 01/04/2013 30/09/2016 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

CRUKD/16/004 SPIRE: A Phase Ib/IIa clinical trial combining DNA Methyltransferase inhibitor SGI110 with cisplatin and gemcitabine chemotherapy in patients with advanced solid tumours including bladder cancer University of Southampton 01/09/2015 28/02/2018 New Agents Committee - Trial Grant Application New Agents Committee

Cree, Professor Ian ian.cree**[ta]**w.nhs.uk

Systematic reviews to underpin the development of a blood test for cancer University of Warwick 01/02/2014 31/12/2015 Scientifc Executive Board - Project Award Scientifc Executive BoardCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

CRUK/11/058: Neo-SCOPE: Neo-adjuvant Study of Chemoradiotherapy in OesoPhageal Cancer Velindre NHS Trust 01/01/2012 31/12/2016 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

CRUK/14/022: SCOPE2 - A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with defnitive chemoradiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET) Velindre NHS Trust 01/01/2015 31/12/2023 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Crosby, Dr Tom CRUK/07/003: SCOPE 1: A randomised phase II/III multi-centre clinical trial of defnitive chemoradiation, with or without cetuximab, in carcinoma of the oesophagus Velindre NHS Trust 01/01/2007 31/12/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Cunningham, Professor David david.cunningham**[ta]**.nhs.uk

CRUKE/11/020: CHEMO-T: CHOP verses GEM-P in the frst line treatment Of T-cell Lymphoma Royal Marsden NHS Foundation Trust 01/10/2011 30/09/2018 Clinical Trials Awards & Advisory Committee - Endorsement - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/06/025: ST03: A randomised phase II/ III study of peri-operative chemotherapy with or without bevacizumab in patients with operable adenocarcinoma of the stomach and gastrooesophageal junction University College London 01/12/2006 30/11/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Cuzick, Professor Jack j.cuzick**[ta]**l.ac.uk

CRUK/04/032 AND CRUK/04/033: IBIS II Queen Mary, University of London 01/04/2004 31/03/2019 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Cancer Prevention Queen Mary, University of London 01/04/2014 31/03/2019 Population Research Committee - Programme Award Population Research Committee

Cvejic, Dr Ana as889**[ta]**.ac.uk

Closing the knowledge gap in post-genomic research: Fast-track functional characterisation of genes implicated in human blood formation and pathologies using zebrafsh as an in vivo model.University of Cambridge 01/10/2012 30/09/2018 New Investigator Committee - Career Development Fellowship New Investigator Committee

Cwynarski, Dr Kate kate.cwynarski**[ta]**.net CRUK/10/023: IESLG-32: Randomised Phase II Trial on primary CT with Methotrexate & Cytarabine +/- Thiotepa & Rituximab, followed by brain irradiation vs.high-dose CT supported by ASCT for immunocompetent patients with CNS lymphom University of Southampton 01/02/2011 31/01/2017 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Committee

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.CRUK/14/044 IELSG 42: International phase II trial assessing tolerability and efcacy of sequential MTX/ Ara-C-based regimen and R-ICE, followed by high dose chemotherapy supported by PBSCT, in patients with systemic B-cell lymphoma with central nervous system involvement at diagnosis or relapse University of Southampton 01/02/2015 31/10/2023 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Davies, Dr Andrew a.davies**[ta]**thampton.ac.uk

CRUK/12/040: IELSG 37 - A randomised, open-label, multicentre, two-arm phase III comparative study assessing the role of involved mediastinal radiotherapy after rituximab containing chemotherapy regimens to patients with newly diagnosed primary mediastinal B-Cell lymphoma (PMBL) University of Southampton 01/05/2013 30/04/2022 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Preclinical development & CRUKD/12/003: A Phase I frst in human trial of anti-CD19 DI-B4 monoclonal antibody in patients with indolent B-cell malignancies University of Southampton 01/07/2009 28/02/2019 New Agents Committee - DD Project Proposal New Agents Committee

Exploratory & preclinical development & CRUKD/16/001 a frst in human Phase I/IIa Study with BI1206, an antibody to Fc gamma receptor IIB (FcgRIIB), and rituximab in patients with CD32+ B cell malignancy (Funded by Leukaemia & Lymphoma Research) University of Southampton 01/11/2014 31/10/2019 New Agents Committee - DD Project Proposal New Agents Committee

Davies, Dr Faith Targeting intracellular protein handling as a strategy for cancer therapy; using Multiple Myeloma as a model Institute of Cancer Research 01/02/2011 31/01/2017 New Investigator Committee - Senior Cancer Research Fellowship New Investigator Committee

Targeting intracellular protein handling as a strategy for cancer therapy; using Multiple Myeloma as a model Institute of Cancer Research 01/10/2011 30/09/2015 New Investigator Committee - Studentship New Investigator Committee

de Bono, Professor Johann johann.de-bono**[ta]**.ac.uk

CRUKE/12/050: A randomised Phase II study of enzalutamide (MDV3100) in combination with AZD5363 in Patients with Metastatic CastrationResistant Prostate Cancer (RE-AKT) Institute of Cancer Research 01/03/2014 28/02/2018 Clinical Trials Awards & Advisory Committee - Endorsement - Feasibility Study Clinical Trials Awards & Advisory Committee

CRUK/11/029: TO-PARP: Trial of Olaparib in Patients with Advanced Castration Resistant Prostate Cancer (AZ/NCRN) Institute of Cancer Research 01/06/2012 30/06/2018 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUKD/08/044 A CR-UK Phase I/II open label trial to evaluate the safety, endocrine eﬀects and anti-tumour activity of abiraterone acetate (CB7630)in patients with Oestrogen (ER+) or Androgen Receptor (AR+) positive refractory advanced or metastatic breast carcinoma Institute of Cancer Research 01/01/2007 31/01/2016 New Agents Committee - DD Project Proposal New Agents CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.Identifcation And Molecular Characterisation Of Metastatic Sporadic Castration Resistant Prostate Cancers (mCRPC) With Homologous Recombination DNA Repair Defects That Can Be Targeted By A Synthetic Lethal Strategy Institute of Cancer Research 01/08/2011 31/10/2015 Science Committee - Biomarker Project Award Science Committee

de Bruin, Professor Marijn m.debruin**[ta]**n.ac.uk

Making results of smoking cessation trials more useful to policy and practice: Identifying the eﬀective behavioural components of smoking cessation support provided to intervention and control groups by applying innovative methods for evidence syntheses University of Aberdeen 01/04/2015 31/03/2018 Population Research Committee - Project Award Population Research Committee

De Piccoli, Dr Giacomo G.de-Piccoli**[ta]**wick.ac.uk

Novel mechanisms through which the S-phase checkpoint pathway preserves genome integrity University of Warwick 01/10/2013 30/09/2019 New Investigator Committee - Career Development Fellowship New Investigator Committee

De Santo, Dr Carmela c.desanto**[ta]**m.ac.uk

Investigating the immunosuppressive microenvironment created by Acute Myeloid Leukaemia using invariant Natural Killer T cells as a novel therapeutic approach.University of Birmingham 01/03/2015 28/02/2021 New Investigator Committee - Career Development Fellowship New Investigator Committee

de Vocht, Dr Frank Cancer mortality and incidence in the British Rubber industry - a 45 year follow-up University of Bristol 01/11/2013 29/02/2016 Population Research Committee - Project Award Population Research Committee

Dearnaley, Professor David david.dearnaley**[ta]**.ac.uk

An evaluation of biomarkers in hypofractionated and dose escalated prostate cancer radiotherapy: TransCHHiP Study Institute of Cancer Research 01/12/2011 30/11/2015 Science Committee - Biomarker Project Award Science Committee

deSouza, Professor Nandita nandita.desouza**[ta]**.ac.uk

Standardization of DWI MRI for quantitative assessment of ovarian cancer and implementation in clinical trials Institute of Cancer Research 01/10/2011 30/09/2016 Science Committee - Biomarker Project Award Science Committee

Difey, Dr John Chromosome Replication The Francis Crick Institute 01/10/2012 30/09/2017 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Dinkova-Kostova, Dr Albena The role of the Keap1/Nrf2 pathway in tumour metabolic adaptation University of Dundee 01/06/2015 31/05/2020 Science Committee - Programme Award Science Committee

Dive, Professor Caroline caroline.dive**[ta]**k.manchester.ac.uk

Assessment of the anti-tumour efcacy and pharmacodynamic eﬀects of combining the Wee1 inhibitor AZD1775 with small cell lung cancer standard of care chemotherapy cisplatin/etoposide or topotecan in unique small cell lung cancer circulating tumour cell derived xenograft models Cancer Research UK Manchester Institute 01/05/2015 30/04/2016 New Agents Committee - PreClinical Grants New Agents CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.Assessment of the anti-tumour efcacy and pharmacodynamic eﬀects of combining the Wee1 inhibitor AZD1775 with the Hsp90 inhibitor AT13387 in unique lung cancer circulating tumour cell derived xenograft models Cancer Research UK Manchester Institute 01/05/2015 30/04/2016 New Agents Committee - PreClinical Grants New Agents Committee

Clinical and Experimental Pharmacology Group University of Manchester 01/01/2014 31/12/2018 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Dobbie, Miss Fiona fona.dobbie**[ta]**r.ac.uk

Developing social network support to improve smoking cessation outcomes for pregnant women living in disadvantaged areas.University of Stirling 01/10/2014 30/09/2015 Population Research Committee - BUPA Foundation Fund - Innovation Grant Population Research Committee

dos Santos Silva, Professor Isabel isabel.silva**[ta]**tm.ac.uk

Breast tissue composition at young ages and its determinants: a study nested within a British birth cohort London School of Hygiene and Tropical Medicine 01/11/2011 31/12/2015 Population Research Committee - Project Award Population Research Committee

Downs, Dr Jessica j.a.downs**[ta]**sex.ac.uk

Analysis of the PBAF and INO80 chromatin remodelling complexes and their impact on genome stability University of Sussex 01/01/2014 31/12/2018 Science Committee - Programme Award Science Committee

Downward, Professor Julian julian.downward**[ta]**ck.ac.uk

Novel approaches to targeting RAS oncogene signaling in cancer The Francis Crick Institute 01/11/2012 31/10/2017 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Dowsett, Professor Mitchell mitch.dowsett**[ta]**.ac.uk

CRUKE/13/031: PALLET: An assessment of the biological and clinical eﬀects of palbociclib with letrozole in the neoadjuvant treatment of ER+ primary breast cancer Institute of Cancer Research 01/07/2014 30/06/2017 Clinical Trials Awards & Advisory Committee - Endorsement - Feasibility Study Clinical Trials Awards & Advisory Committee

Integration of 2 week Ki67 with IHC4 in the POETIC trial Institute of Cancer Research 01/11/2013 31/10/2016 Science Committee - Biomarker Project Award Science Committee

Drew, Dr Yvette yvette.drew**[ta]**.ac.uk

Preclinical combination studies of imatinib and olaparib in Homologous recombination stratifed relapsed ovarian cancer Newcastle University 01/06/2015 31/05/2016 New Agents Committee - PreClinical Grants New Agents Committee

D'Sa, Dr Shirley shirley.dsa**[ta]**h.nhs.uk

CRUK/14/032 IDRIS: Phase III randomised trial of immunomodulatory therapy in high risk solitary bone plasmacytoma University College London 01/08/2015 31/07/2024 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Dunlop, Professor Malcolm malcolm.dunlop**[ta]**m.ed.ac.uk

Dissecting the genetics of colorectal cancer University of Edinburgh 01/01/2011 31/12/2015 Science Committee - Programme Award Science Committee

Dunning, Dr Alison Genetic Epidemiology of Cancer, Sample Handling, Genotyping and Mutation Detection Core University of Cambridge 01/10/2013 30/09/2018 Science Committee - Programme Award Science CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

CRUK/08/037 ARTemis: Avastin Randomised Trial with neo-adjuvant chemotherapy for patients with early HER 2 negative breast cancer University of Cambridge 01/05/2009 30/04/2018 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/13/020: A randomized phase II study evaluating the role of maintenance therapy with cabozantinib vs placebo in High Grade Uterine Sarcoma (HGUS) after stabilization or response to CT following surgery or in metastatic 1st-line treatment (International Rare Cancers Initiative study - IRCI 006) NHS Greater Glasgow and Clyde 01/01/2015 31/05/2020 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Easton, Professor Douglas Epidemiological study of BRCA1 and BRCA2 mutation carriers (EMBRACE) University of Cambridge 01/02/2014 31/01/2017 Population Research Committee - Project Award Population Research Committee

Genetic Epidemiology of Cancer University of Cambridge 01/10/2013 30/09/2018 Science Committee - Programme Award Science Committee

Eccles, Professor Diana Prospective study of Outcomes in Sporadic versus Hereditary breast cancer University of Southampton 01/03/2015 28/02/2017 Science Committee - Biomarker Project Award Science Committee

Edmondson, Professor Richard richard.edmondson**[ta]**chester.ac.uk

CRUK/10/056: PARAGON: Phase II study of aromatase inhibitors in women with potentially hormone responsive recurrent/metastatic gynaecological neoplasms University of Glasgow 01/02/2011 31/07/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/10/056: Translational research in potentially hormone responsive recurrent/metastatic gynaecological neoplasms - TRANS PARAGON University of Glasgow 01/06/2012 31/05/2016 Clinical Trials Awards & Advisory Committee - Sample Collection Clinical Trials Awards & Advisory Committee

Edmunds, Professor John john.edmunds**[ta]**tm.ac.uk

Predicting the impact of HPV vaccination on cervical cancer: the interaction with screening London School of Hygiene and Tropical Medicine 01/07/2011 29/02/2016 Population Research Committee - Project Award Population Research Committee

Eeles, Professor Rosalind lorna.barakzai**[ta]**.ac.uk

Translational studies in prostate cancer genetics: an oncogenetics programme Institute of Cancer Research 01/10/2014 30/09/2019 Science Committee - Programme Award Science Committee

FULL STUDY International Cancer Genome Consortium: The Prostate Cancer Initiative: a UK-North American-French- Asian-Partnership (ICGC-PROSTATE CANCER) Institute of Cancer Research 01/09/2011 31/08/2016 Scientifc Executive Board - Project Award Scientifc Executive Board

Eisen, Professor Tim tgqe2**[ta]**.ac.uk

CRUK/06/004: SORCE - A phase III randomised controlled study comparing sorafenib with placebo in patients with resected primary renal cell cancer carcinoma at high or intermediate risk of relapse University College London 01/04/2006 31/03/2018 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

Symptoms associated with cancer in the UK general population: Understanding prevalence, patterning and response to provide an evidence base for the development of interventions to reduce time to presentation University of Aberdeen 01/10/2014 30/09/2017 National Awareness and Early Diagnosis Initiative - Project Award National Awareness and Early Diagnosis Initiative

Elliott, Dr Martin CRUK/02/013: High Risk Neuroblastoma Study 1 of SIOP - Europe (Extension) University of Birmingham 01/03/2007 28/02/2018 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Elliott, Professor Tim tje**[ta]**on.ac.uk

Peptide selection in the MHC I antigen processing pathway and its relevance to cancer University of Southampton 01/02/2015 31/01/2020 Science Committee - Programme Award Science Committee

Enver, Professor Tariq t.enver**[ta]**.ac.uk

Characterisation of leukaemic stem cell biology in childhood AML University College London 01/01/2012 31/12/2016 Science Committee - Programme Award Science Committee

Kaposi's sarcoma herpesvirus: The role of latency transcripts in lymphatic endothelial cell biology and oncogenesis University College London 01/11/2011 30/06/2016 Science Committee - Programme Award Science Committee

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